Research compound
MOTS-c
A mitochondrial-derived peptide studied in energy metabolism.
Also discussed as: MOTS C
THE RESEARCH QUESTION
What is being investigated?
Foundational work examined metabolic regulation and insulin sensitivity, including in mice.
EVIDENCE SNAPSHOT
Mainly preclinical
Results from laboratory models do not show that taking MOTS-c improves human exercise performance, reverses metabolic disease or extends lifespan.
LIMITS & SAFETY
What should you know?
Human administration safety is not established.
FOLLOW THE EVIDENCE
Sources & further reading
- MOTS-c: metabolism and insulin sensitivity research (2015) ↗Preclinical study
- FDA: safety information for bulk substances used in compounding ↗Regulator
Checked 8 October 2026. Sources may describe different populations, formulations and jurisdictions. This overview is not a systematic review or individual medical advice.
PUT THE EVIDENCE IN CONTEXT
Questions about what you’ve read?
Request an educational conversation with Matthew about the evidence and questions to raise with your medical professional.